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The review situates Dihexa within the renin-angiotensin systems central nervous system arm, summarizes the HGF/c-Met activation hypothesis, and surveys behavioral pharmacology in rodent cognitive models

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Research on autoimmune encephalomyelitis revealed that HGF, as an immune modulator, significantly hindered DC antigen presentation, leading to an increase in CD25 + Foxp3 + regulatory T cells and boosting IL-10 production [95]